Abstract
We analyzed the additional prognostic information from cytopathologic data obtained at the time of uveal melanoma irradiation. Fine-needle aspiration biopsies (FNABs) were performed and reviewed in a masked manner. These data and standard prognostic variables were correlated with survival and local tumor recurrence using Kaplan-Meier and Cox model statistical techniques. Cytopathologic assessment of cell type added to prognostic accuracy. In 116 patients, the percentage of epithelioid cells on FNAB and ciliary body involvement were most strongly correlated with melanoma-related mortality. FNAB data improved our prognostic accuracy in irradiated uveal melanoma patients.
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