Abstract
AbstractThe results of XANES and Mössbauer spectroscopy studies of organic samples of [Fe(Hka)3] (Hka = kojic acid) and [Fe(etmal)3] (etmal = ethyl maltol) are presented and discussed in terms of their application in characterization of the local electronic state of Fe3+. In case of [Fe(etmal)3], a tiny increase in covalency of iron bonds was found. The local iron states in tissues have been concluded from x‐ray absorption near‐edge structures (XANES) spectra, compared with spectra obtained for the organic samples. Significant increase of iron concentration in pathological cells of the prostate was shown by the synchrotron radiation‐induced x‐ray emission (SRIXE) method. XANES analysis of healthy and cancerous tissue samples suggested higher iron oxidation state in pathological cells. This result may be a hint for understanding the role of iron in carcinogenesisand opens up the same possibility of using XANES spectroscopy as a diagnostic tool in oncology. The correlation between results obtained by XANES and Mössbauer spectroscopy may be helpful in overcoming the limitations characteristic of both of the methods in the determination of the iron valence and spin states in tissues. Copyright © 2008 John Wiley & Sons, Ltd.
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