Iron treatment in sideropenic intravascular hemolysis due to insufficiency of Starr-Edwards valve prostheses.

Abstract

Article1 April 1967Iron Treatment in Sideropenic Intravascular Hemolysis Due to Insufficiency of Starr-Edwards Valve ProsthesesRALPH D. REYNOLDS, CHARLES A. COLTMAN JR., BARRY M. BELLERRALPH D. REYNOLDSSearch for more papers by this author, CHARLES A. COLTMAN JR.Search for more papers by this author, BARRY M. BELLERSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-4-659 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe association of hemolysis and the use of intravascular prosthetic valves was first noted in dogs by Sarnoff and Case (1) and Stohlman, Sarnoff, Case, and Ness (2). This was considered a mechanical problem resulting from red cell trauma. The initial observation by Sayed and associates (3) of similar intravascular erythrocyte destruction in a child whose ostium primum defect was repaired with a Teflon® patch was followed by numerous reports of hemolysis associated with intracardiac use of ball-valve prostheses (3-14), Teflon patches (15-18), and Teflon cusps (12-20). In each instance a fairly uniform hemolytic syndrome was reported, characterized by fragmented...