Iron Supplementation Necessities for Subjects with Celiac Disease in KSA –A Retrospective Study (P12-040-19)

Abstract

ObjectivesTo assess the iron (Fe) supplementation necessities for subjects with celiac disease (CD) in KSA. MethodsThe study was conducted among the subjects with CD registered in King Abdulaziz Medical City (KAMC), KSA for medical care during 2008–18. Those who are pregnant/lactating or with blood loss due to non-CD causes/gastrointestinal (GI) abnormalities/chronic disease of liver/kidney/febrile diseases/cancer/metabolic disorders were excluded from the study. The design of the study was retrospective cross-sectional. The data of the subjects with CD entered in the Hospital Information system of KAMC was used. Accordingly, 71 subjects with CD were selected by using convenient sampling technique.Demography, clinical manifestations, hematological and Fe profile of the subjects were studied. SPSS Version 22 was used for data analysis. Frequencies, percentages and mean + SD, Student’s t and non-parametric Mann-Whitney U tests were used. P-value of <0.05 considered as statistically significant. IRB of KAIMRC, Riyadh approved the study. ResultsAdults formed 54.8% of the subjects, children and females formed 31% and 78.9% respectively. Diarrhea and vomiting were the major clinical manifestations observed among 55% of the subjects. Anthropometric data indicated that 38.3% of them was malnourished. Reduced RBC counts perceived among 40.1% of the subjects. Among them, 88.23% were females while 18.3% were with low WBC count. Platelet counts < normal were exhibited by 12.7%. MCV, MCHC, and Hematocrit (HCT) values were lower congruently for 16.9, 69 and 41% (66.66% were females) of the subjects. Iron Deficiency Anemia (IDA) pointed out by low hemoglobin (Hb) level was observed in 38.02%. Of them, 88.19% were females. Abridged Serum iron was detected in 67.59% (85.41% are females) while increased TIBC values were shown by 22.9%. Of the subjects (22.53%) with low serum ferritin(SF) values 68.75% were females. There was a significant difference between the values of RBC count, MCV, MCHC, HCT, Hb and SF levels of both genders. ConclusionsThe study signifies the importance of the provision of Fe supplements for subjects with CD. Females more than the males with CD are at risk for IDA. Funding SourcesNIL. Supporting Tables, Images and/or Graphs▪