Iron status, FGF23 and rickets in The Gambia

Abstract

Event Abstract Back to Event Iron status, FGF23 and rickets in The Gambia VB Braithwaite1*, LMA Jarjou2, GR Goldberg1, 2 and A Prentice1 1 University of Cambridge, MRC Human Nutrition Research, United Kingdom 2 MRC Keneba, Gambia Recent studies have suggested a relationship between iron status and circulating fibroblast growth factor-23 (FGF23). Serum ferritin has been identified as a negative predictor of FGF23 [1] and conversely FGF23 has been shown to be elevated by intravenous injections with iron polymaltose [2].{BR}Iron deficiency anaemia is common in The Gambia and elevated FGF23 has been implicated in the aetiology of Gambian rickets [3]. This study aimed to assess the prevalence of elevated FGF23 and low haemoglobin (Hb) in Gambian children (0.5-18yrs) and to investigate whether a relationship exists between them. {BR}We conducted a retrospective analysis on data from children with a personal or family history of rickets-like bone deformity (BD, n=115). Data from local community children (LC, n=369) were used for comparison. Hb was analysed in fresh, overnight-fasted blood samples on a blood-gas analyser (ABL77) and WHO definitions for anaemia were used. C-terminal FGF23 was measured by Immutopics; the upper-limit reference range was 150 RU/ml. Linear regression was used to determine the relationship between Hb and FGF23 (both transformed to natural logarithms) with adjustments for age and sex. Logistical models were used for categorical analysis.{BR}14% of BD were anaemic compared to 6% of LC (p=0.001). 10% of BD had FGF23>900 RU/ml compared to 1% of LC (p<0.0001). There was a significant correlation between FGF23 and Hb (lnFGF23=9.46-1.73lnHb, R2=16.0%, p<0.0001). When split between groups, Hb was a strong negative predictor of FGF23 in BD (lnFGF23=17.71-4.96lnHb, R2=27.2%, p<0.0001) but only weakly for LC (lnFGF23=6.98-0.82lnHb, R2=9.9%, p=0.03). The Hb x group interaction was highly significant (p<0.0001) demonstrating differences between BD and LC in the slopes of the relationship. {BR}The findings that Hb is a negative predictor of FGF23, that the slope is steeper in BD and that high FGF23 and low Hb are more prevalent in BD suggest that iron maybe involved in FGF23 metabolic pathways and that there is a link between Hb and FGF23 in the aetiology of Gambian rickets. {BR}1. Durham, B.H., et al. Assoc Clin Biochem 2007.44:p.463-466.{BR}2. Schouten, B.J., et al. J Clin Endocrinol Metab 2009.94:p.2332-2337.{BR}3. Prentice, A., et al. Bone 2008.42:p.788-797. Keywords: Bones, Bone Research Conference: 2011 joint meeting of the Bone Research Society & the British Orthopaedic Research Society, Cambridge, United Kingdom, 27 Jun - 29 Jun, 2011. Presentation Type: Oral Topic: Abstracts Citation: Braithwaite V, Jarjou L, Goldberg G and Prentice A (2011). Iron status, FGF23 and rickets in The Gambia. Front. Endocrinol. Conference Abstract: 2011 joint meeting of the Bone Research Society & the British Orthopaedic Research Society. doi: 10.3389/conf.fendo.2011.02.00008 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 30 Sep 2011; Published Online: 30 Sep 2011. * Correspondence: Prof. VB Braithwaite, University of Cambridge, MRC Human Nutrition Research, Cambridge, United Kingdom, vb287@cam.ac.uk Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers VB Braithwaite LMA Jarjou GR Goldberg A Prentice Google VB Braithwaite LMA Jarjou GR Goldberg A Prentice Google Scholar VB Braithwaite LMA Jarjou GR Goldberg A Prentice PubMed VB Braithwaite LMA Jarjou GR Goldberg A Prentice Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.