Abstract
To explore relationships between iron status and lymphocyte SHMT activity (ACT) and abundance (ABN), 118 postmenopausal women (54.3 y) enrolled in SIRBL (Soy Isoflavones for Reducing Bone Loss) study and 105 young women (21.2 y) were studied. Serum ferritin, folate, and vitamin B‐12, plasma total homocysteine (tHcy) and pyridoxal phosphate (PLP), lymphocyte SHMT ACT and ABN were determined. Subjects in the first (4.8 ng/mL; 93% premenopausal) and fifth (92.6 ng/mL; 98% postmenopausal) quintiles of serum ferritin were compared. The fifth quintile had higher median BMI (25 vs 22 kg/m2; p<0.02), plasma PLP (p<0.0001), total homocysteine (p<0.05), and SHMT ABN (p<0.0001), but significantly lower SHMT ACT (p<0.02) than first quintile. Ferritin quintile Folate ng/mL B‐12 pg/mL PLP nmol/L tHcy nmol/L SHMT ACT cpm/ug protein SHMT ABN relative density First (n) 14.2 (45) 597 (45) 61.7 (45) 6.4 (45) 43.6 (27) 1.1 (21) Fifth (n) 13.1 (45) 521 (45) 93.9 (45) 6.6 (45) 13.0 (14) 12.3 (31) Increased iron status may enhance SHMT expression, favoring thymidine synthesis over Hcy remethylation, thus warranting further investigation.Funded by USDA Special Grant, NWRC, Iowa State University.
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