Abstract
Radiotherapy is recommended as a modality for cancer treatment in clinic. However, cancerous cells were resistant to therapeutic irradiation due to its DNA repair. In this work, single-walled carbon nanotubes with unique physical properties of hollow structures and high specific surface area were introduced as carrier for iron-palladium (FePd) to obtain iron-palladium decorated carbon nanotubes (FePd@CNTs). On one hand, FePd nanoparticles possess significant ability in radiosensitization as previously reported. On the other hand, carbon nanotubes offer higher efficiency in crossing biological barriers, inducing the accumulation and retention of FePd nanoparticles within tumor tissue. In order to verify the radiosensitization effect of FePd@CNTs, both in vitro and in vivo experiments were conducted. These experiments showed that the FePd@CNTs exhibited remarkably better radiosensitization effect and more obvious accumulation than FePd NPs, suggesting a potential of FePd@CNTs in radiosensitization.
Highlights
Radiotherapy is a cancer therapy method that uses radiation rays to kill tumor cells directly or indirectly
They were reared in a specific pathogen-free, temperature and humidity-controlled environment with clean food and water in their cages
Mice were randomly separated into six groups (5 mice per group) and treated as follows: (i) Control (100 μL PBS), (ii) FePd@CNTs (i.v., injection; 100 μL, 200 μg/mL), (iii) RT (6 Gy), (iv) FePd NPs (i.v., injection; 100 μL, 200 μg/mL) +RT (6 Gy), and (v) FePd@CNTs (i.v., injection; 100 μL, 200 μg/mL) +RT (6 Gy)
Summary
Radiotherapy is a cancer therapy method that uses radiation rays to kill tumor cells directly or indirectly. Radiation leads to DNA double strand breaks (DSBs), thereby causing apoptosis of cancer cells. Radiation resistance caused of cancerous cells induced by the hypoxic in tumor tissues is another barrier that impairs the effectiveness of radiotherapy (Carlson et al, 2006; Stewart et al, 2011). Reactive oxygen species (ROS) in cells lead to apoptosis (Hirayama et al, 2009; Yang et al, 2017). Two main strategies appears to be the key to solve these problems: (1) accurate tumor delineation and image guidance technologies with higher resolution (Bhide and Nutting, 2010); (2) highefficiency radiosensitizers to increase the radiation deposition in tumors (Zhu et al, 2020a), reduce tumor hypoxia (Lyu et al, 2020b) and increase the production of reactive oxygen species in tumor cells (Liu et al, 2020)
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