Abstract
The present paper describes the results of a comparative histological and quantitative analysis of iron distribution in tissues of β 2m−/− and β 2m+/− mice of different ages. Progressive hepatic iron overload, indistinguishable from that observed in human hemochromatosis, was found only in mice homozygous for the mutated β 2m gene. Total iron measurements done by flame atomic absorption showed statistically significant differences between liver samples from 5 β 2m+/− heterozygotes (468 ± 174 μg/g of dry weight) and 9 mice homozygous for the mutated β 2m gene with average total hepatic iron levels of 1583 ± 424 μg/g of dry weight.
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