Abstract
The role of the proteins of iron transport and storage and of the other intracellular ligands of iron (both protein and non-protein) is to ensure the facile transfer of iron from sites where it is abundant to sites where it is required. That there must be a pool of free iron in equilibrium with the protein-bound iron is a thermodynamic necessity. However, the mechanisms by which the potentially toxic consequences of the interaction between the pool of free iron and molecular oxygen are avoided, remain one of the mysteries of living organisms on which we have, as yet, only a poor and fragmentary understanding.
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