Abstract
Iron, Inflammation, and Malaria in the Pregnant Woman and Her Child: Saving Lives, Saving Brains.
Highlights
The battle for iron between host and pathogen in children living in malaria-endemic areas is fierce, and new evidence presented by Brickley and others[1] in this month’s issue suggests it may well begin before birth
This group showed that iron deficiency in children living in a malaria-endemic area of Tanzania was associated with a decreased risk of malaria and death.[2]
In the present study conducted in the same cohort, the authors show that higher cord blood concentrations of the iron regulatory and inflammatory protein hepcidin predict a significantly greater risk of anemia but a lower risk of malaria and all-cause mortality during early childhood
Summary
The battle for iron between host and pathogen in children living in malaria-endemic areas is fierce, and new evidence presented by Brickley and others[1] in this month’s issue suggests it may well begin before birth. This group showed that iron deficiency in children living in a malaria-endemic area of Tanzania was associated with a decreased risk of malaria and death.[2] In the present study conducted in the same cohort, the authors show that higher cord blood concentrations of the iron regulatory and inflammatory protein hepcidin predict a significantly greater risk of anemia but a lower risk of malaria and all-cause mortality during early childhood.
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