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Abstract
AbstractA iron‐catalyzed free radical cascade reaction of allyl alcohols with N‐substituted maleimides for accessing poly‐substituted γ‐butyrolactones has been developed. In this protocol, various allyl alcohols can open N‐substituted maleimide rings to form allyl ester intermediates, and the allyl ester intermediates can be converted into an allyl ester alkyl radicals and undergo intramolecular free radical addition cyclization to form a polysubstituted γ‐butyrolactones. In this protocol, spiro γ‐butyrolactone compounds can be also synthesized. Meanwhile, the strategy could be applied to further construct a fully substituted tetrahydrofuran. The reaction is not sensitive to oxygen or moisture and has been performed on gram‐scale.magnified image
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