Iron Hydroxide/Oxide-Reduced Graphene Oxide Nanocomposite for Dual-Modality Photodynamic and Photothermal Therapy In Vitro and In Vivo.

Wei-Jane Chiu,Chia-Hua Lin,Lingyan Yang,Chih-Ching Huang,Jiantao Yu,Yi-Chun Chen,Shih-Wei Huang

doi:10.3390/nano11081947

Abstract

Minimal invasive phototherapy utilising near-infrared (NIR) laser to generate local reactive oxygen species (ROS) and heat has few associated side effects and is a precise treatment in cancer therapy. However, high-efficiency and safe phototherapeutic tumour agents still need developing. The application of iron hydroxide/oxide immobilised on reduced graphene oxide (FeOxH–rGO) nanocomposites as a therapeutic agent in integration photodynamic cancer therapy (PDT) and photothermal cancer therapy (PTT) was discussed. Under 808 nm NIR irradiation, FeOxH–rGO offers a high ROS generation and light-to-heat conversion efficiency because of its strong NIR absorption. These phototherapeutic effects lead to irreversible damage in FeOxH–rGO-treated T47D cells. Using a tumour-bearing mouse model, NIR ablated the breast tumour effectively in the presence of FeOxH–rGO. The tumour treatment response was evaluated to be 100%. We integrated PDT and PTT into a single nanodevice to facilitate effective cancer therapy. Our FeOxH–rGO, which integrates the merits of FeOxH and rGO, displays an outstanding tumoricidal capacity, suggesting the utilization of this nanocomposites in future medical applications.

Highlights

IntroductionPhototherapy of solid tumours is an attractive method for non-invasive treatment [1,2,3].Phototherapy typically involves two unique properties of photosensitisers: generating toxicROS (reactive oxygen species), photodynamic cancer therapy (PDT) (photodynamic therapy) or heat (photothermal therapy, photothermal cancer therapy (PTT)) capable of killing cancer cells via photoablation [4]
Phototherapy of solid tumours is an attractive method for non-invasive treatment [1,2,3].Phototherapy typically involves two unique properties of photosensitisers: generating toxicreactive oxygen species (ROS), photodynamic cancer therapy (PDT) or heat capable of killing cancer cells via photoablation [4]
NanoFeOxH were distributed on the surface of reduces GO (rGO) (Figure S1), forming FeOxH–rGO (Figure 1A)

Summary

Introduction

Phototherapy of solid tumours is an attractive method for non-invasive treatment [1,2,3].Phototherapy typically involves two unique properties of photosensitisers: generating toxicROS (reactive oxygen species), PDT (photodynamic therapy) or heat (photothermal therapy, PTT) capable of killing cancer cells via photoablation [4]. Phototherapy of solid tumours is an attractive method for non-invasive treatment [1,2,3]. Phototherapy typically involves two unique properties of photosensitisers: generating toxic. ROS (reactive oxygen species), PDT (photodynamic therapy) or heat (photothermal therapy, PTT) capable of killing cancer cells via photoablation [4]. As photosensitisers are typically harmless without light, selective illumination allows precise tumour treatment, reducing side effects to healthy tissues [4]. Numerous current PDT photosensitisers have been excited by visible light or ultraviolet (UV), limiting penetration depth and cancer treatment efficiency [3]. PDT has been proven to damage vascular endothelial cells in the therapeutic process [5]. PTT is a hopeful technique for cancer treatment using non-poisonous light-responsive materials, which is favourable over traditional treatment, Nanomaterials 2021, 11, 1947.

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Results

Conclusion