Iron‐Facilitated Oxidative Dehydrogenative CO Bond Formation by Propargylic CH Functionalization

Abstract

The formation of carbon–heteroatom bonds is one of themost attractive and fundamental transformations in organic synthesis. For example, the construction of C O bonds plays an important role in producing alcohols, ethers, and esters in the synthesis of drugs, materials, and natural products. In general, great progress has been made in C O bond formation from carbon–halide bonds, although prefunctionalization of the substrates was often required and halidecontaining by-products were formed during the process (Scheme 1a). Thus, the alternative strategy involving direct