Abstract
INTRODUCTION 345 STRUCTURE AND FUNCTION OF FERRITIN AND TRANSFERRIN RECEPTOR 348 THE IRON-RESPONSE ELEMENT ........ ..... . . . . . . . . ... . . . ... . . . . . . . . . . . . . . . . . . . . . . .. .. .. . . . . 349 STRUCTURE AND FUNCTION OF THE IRON-RESPONSIVE ELEMENT BINDING PROTEINS (IRE-BPs) 35 1 Conservation of IRE-BPs.. . .. . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . .. . . . . ... . . . . . . . . . . . .. . . . . .. . . 35 1 Purification, Cloning, and Characterization of IRE-BPs .. ..... ........ ...... . . . . . . . . . . . . 351 IRON-DEPENDENT POSTTRANSCRIPTIONAL REGULATION BY IRE-BPs . . ..... , 353 Translational Regulation by IRE-BPs . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . .. . . . . . . .. . . . 353 Stabilization of TjR mRNA by IRE-BPs.... .. .... . . . .. . . . .. . . . . . .. . . . . . . . . . . . ... . . .. . . . . . . . .. 357 A Model for the Coordinate Regulation of Ferritin and TjR by IRE-BPs .. 358 MECHANISM OF ACTIVATION OF IRE-BPs BY IRON 360 RELATED FAMILIES OF IRE-BPs 363 CONCLUDING REMARKS 363
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