Iron deficiency and obesity in pre-school children

Abstract

PurposeThe purpose of this review was to highlight the association between ID and obesity in toddlers and preschool children.Design/methodology/approachThis review aimed to review and evaluate literature of the published research discussing the relationship between ID and overweight and obesity in children under the age of 5 years. Conflicting results of iron status in overweight and obese children under the age of 5 years had been found. However, most articles concluded that ID is associated significantly with overweight and obesity in children because of the systemic inflammatory reaction which is considered the major cause of ID; hepcidin with its resultant effect in decreasing duodenal absorption of iron; in addition to other causes including dietary and genetic factors.FindingsConflicting results of iron status in overweight and obese children under the age of 5 years had been found, but most articles concluded that ID is associated significantly with overweight and obesity in children, with systemic inflammatory reaction being the major cause through hepcidin with its resultant effect in decreased duodenal absorption of iron, in addition to other causes including dietary and genetic factors.Originality/valueMany nutrients have been associated with weight gain and ID development. Unbalanced diet either in excess or shortage may affect weight status and serum iron profile. Future research is needed to study more in depth the association between ID and obesity in toddlers and preschool children and to further explore the various factors involved in pathogenesis of ID.