Abstract
Background: Febrile seizures in children are a common problem. Iron deficiency anaemia is known, among other contributing factors, to be an aggravating factor in febrile seizures. Iron deficiency anaemia is a condition that can be avoided and managed. The study goal was to identify iron deficiency anaemia as a trigger factor for febrile seizures (FS). To determine the association between Iron Deficiency Anemia (IDA) and the first episode of febrile seizures (FFS). Subjects and Methods: Investigation like hemoglobin, blood indices (MCV, MCH), and serum iron and serum ferritin are done for detection of iron deficiency anaemia and their relationship with the first episode of febrile seizure was observed. Results: In our study comprising 50 cases and 50 controls, 58% (29) of cases were diagnosed as IDA with FS, 18% (9) of controls were diagnosed as IDA with Febrile Illness (FI). This suggests IDA as a risk factor for febrile seizures with a significant P value of <0.001. Among 50 cases 42% (21) cases have FS without IDA and among 50 controls 82% (41) controls have FI without IDA were present in the current study. Conclusion: IDA was more common in children with FS than in those with febrile illness (FI) disease alone. The result suggests that the IDA can be a contributing factor to the FFS. Screening of IDA of children with FFS should be regarded. Fever can worsen the negative effects of anaemia or iron deficiency on the brain, which can lead to seizures.
Highlights
Febrile Seizures (FS) is the most common convulsive disorder of children and occurs in 2-5% of the overall number of children were impacted per year. [1] Febrile Seizure was classified as fever-related seizures
[1] Trigger factors for this condition include a family history of convulsion or febrile seizures (FS), brain injury, mothers who consume or drink alcoholic drinks and high fever. [2–6] Since FS has the ability to progress to convulsion and epilepsy, several trials have been carried out to determine remedial risk factors for FS to decrease the occurrence and, subsequently, epilepsy and convulsion. [2,3,7–9] The WHO 1995–2011 global anaemia report states that nearly 43% of babies, 38% of pregnant women, and 29% of nonpregnant women and 29% of all reproductive-age people worldwide suffered from anaemia, equal to 273 million young teenagers, 496 million non-pregnant, and 32 million pregnant women
The association between iron deficiency anaemia and febrile seizures was previously investigated without any definitive results and more data was presented for this study
Summary
Febrile Seizures (FS) is the most common convulsive disorder of children and occurs in 2-5% of the overall number of children (or 4.8/1000) were impacted per year. [1] Febrile Seizure was classified as fever-related seizures. Iron deficiency is postulated as a factor leading to febrile seizures in children and is reversed. The study goal was to identify iron deficiency anaemia as a trigger factor for febrile seizures (FS). To determine the association between Iron Deficiency Anemia (IDA) and the first episode of febrile seizures (FFS). Results: In our study comprising 50 cases and 50 controls, 58% (29) of cases were diagnosed as IDA with FS, 18% (9) of controls were diagnosed as IDA with Febrile Illness (FI) This suggests IDA as a risk factor for febrile seizures with a significant P value of
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