Iron Chelation with Desferrioxamine.

Abstract

s1 April 1964Iron Chelation with Desferrioxamine.John R. Walsh, M.D., F.A.C.P., Robert E. Mass, M.D., Frederic W. Smith, M.D., Verna E. Lange, B.S.John R. Walsh, M.D., F.A.C.P.Search for more papers by this author, Robert E. Mass, M.D.Search for more papers by this author, Frederic W. Smith, M.D.Search for more papers by this author, Verna E. Lange, B.S.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-4-728_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDesferrioxamine (DF), an iron chelating substance, was given parenterally to four patients with idiopathic hemochromatosis, eight patients with cirrhosis of the liver associated with various degrees of iron stores, two patients with hemosiderosis related to blood transfusions, and two control patients. Control patients excreted insignificant amounts of iron in their urine (< 2.0 mg/24 hr), compared with patients with hemochromatosis and hemosiderosis (2.5 to 45 mg/24 hr). Clinical and pathological differentiation of idiopathic hemochromatosis from the hemosiderosis seen with Laennec's cirrhosis was difficult; some patients with the latter exhibited urinary iron excretion patterns similar to patients with hemochromatosis. Therefore, urinary... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Portland, Oregon PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1964Volume 60, Issue 4Page: 728-728KeywordsBlood transfusionCirrhosisExcretionHemochromatosisLiverUrine Issue Published: 1 April 1964 PDF DownloadLoading ...