Abstract
The main objective of the current study is to evaluate the level and overload of serum ferritin in multi-transfused beta Thalassemia major patients. There is an earnest need to defend the chelation treatment and to make mindfulness about the results of serum ferritin in the patients beta Thalassemia major. This is a Cross sectional analytical study performed in Fatimid foundation Hayatabad, Peshawar, Khyber Pakhtunkhwa province of Pakistan. Those patients who has beta thalassemia major are included in this study. In this study there are total 108 patients in which 54 males and 54 females. The highest mean of serum ferritin level in the category of male was in the age of 12 years were finds 8160.5 ng/mL. Among the female the highest mean of ferritin level was in the age of 17 years were finds 13,349.5 ng/mL. In this study majority of patient’s revealed much high levels of serum ferritin. These levels reveal insufficient chelation. Appropriate chelation of iron load can improve the quality of the life of these patients. The low level of education, Poverty problems, and insufficient health care facility of are the main obstacle in the effective management of ferritin overload in thalassemia patients.
Highlights
Iron overload progress of increased mortality and organThalassemia is the name of a collectionThalassemia Individuals can develop an impairment
This study shows that Ferritin increase with age in both non-transfused and transfused patients of thalassemia when the overload of iron is extreme
It shows that levels of Ferritin can rise as a result of harm to the organs, like as the spleen and liver[11] but in this study it is found that level of Ferritin is apparently rises with increasing in the number of blood
Summary
Iron overload progress of increased mortality and organThalassemia is the name of a collectionThalassemia Individuals can develop an impairment. Iron overload progress of increased mortality and organ. Iron overload weakens of genetic blood syndromes described by iron burden in their bodies, from itself immune system, and placing patients at anemia due to greater destruction of red with illness or after regular transfusions of larger risk of illness and infection.[9,10,11,12,13] blood cell. Excess iron could effect in harm to globin take place in a group of genetic heart, liver and the endocrine system that Pathophysiology hemolytic anemia’s called thalassemia. One particle of chelator bind one iron excretion can be increased by raising of protein, two α and two β globin chains molecule of iron shaping a profoundly sta- the deferiprone dose with above the widely organized into a hetero tetramer. The ble hex dentate complex of iron ferrioxam- used treatment of the 75 mg/kg body weight
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