Iron-catalyzed synthesis of polysubstituted pyrrolesvia [4C+1N] cyclization of 4-acetylenic ketones with primary amines

Abstract

A highly efficient iron-catalyzed approach to polysubstituted pyrroles has been developed through the [4C+1N] cyclization of 4-acetylenic ketones with primary amines, leading to the synthesis of a variety of tetra- and fully-substituted pyrroles as well as fused pyrrole derivatives in good to excellent yields.