Iron-catalyzed intermolecular 1,2-difunctionalization of alkenes with nucleophiles and using di-tert-butyl peroxide as the methylation reagent

Abstract

An Fe(II)-catalyzed three-component 1,2-difunctionalization of alkenes with di-tert-butyl peroxide as the methylation reagent has been reported. Employing FeSO4 as the catalyst allows various of alkenes 1,2-methylamination, and 1,2-methylarylation, which rely on a wide spectrum of nucleophiles, such as aromatic amines, pyrrole, and indoles. This protocol is characterized by its simplicity which allowing the rapid building of complex molecules from simple starting materials.