Iron-catalyzed Csp3[sbnd]Csp3 bond formation via dehydrative cross coupling reaction: Facile access to new hybrid dihydroquinazolines having quinoline, isoquinoline, quinoxaline and azoles

Abstract

An operationally simple, efficient and straight forward approach was developed for the synthesis of new hybrid nitrogen heterocycles bearing dihydroquinazoline with quinoline, isoquinoline, quinoxaline and azole via iron-catalyzed dehydrative cross coupling reaction between heterocyclic aminol and 2-methyl azaarenes. Furthermore, this protocol applied to couple simple methyl ketones to achieve C4-alkylated-dihydroquinazolines with broad substrate scope.