Abstract

Co‐occurrence of zinc (Zn) and iron (Fe) deficiencies is common. The epidemiological studies suggested dietary origin of the co‐occurrence. The aim of this study was to test whether Fe deficiency affects Zn kinetics using rats and the stable Zn tracer. Forty 4‐wk‐old male SD rats were assigned into 4 dietary groups of 10: Zn deficiency (ZD), Fe deficiency (FD), Zn/Fe deficiency (ZFD), and Control (AIN‐93G). After rats were fed experimental diets for 4 weeks, baseline blood was collected from the jugular vein and the intravenous 67‐Zn tracer was administered via the femoral vein. Then, blood samples were collected 2‐128 min after the intravenous dose. The plasma 67‐Zn/68‐Zn isotope ratios were measured using ICP‐MS, and Zn kinetic parameters were calculated using the two‐compartment model. The Zn kinetic parameters of FD were not different from those of Control. The rats in ZD had the significantly smaller central and peripheral Zn pool sizes, and the significantly smaller Zn transfer rate between the two compartments and Zn loss from the system. The rats in ZFD had the significantly smaller Zn transfer rate and Zn loss, whereas the Zn pool sizes were not different. In conclusion, simple Zn deficiency induces changes in Zn kinetics. Although simple Fe deficiency does not affect Zn kinetics, it modulates Zn deficiency‐induced changes in Zn kinetics.

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