Abstract
The rate of absorption and red blood cell (RBC) incorporation of Fe by infants fed an iron-supplemented formula designed for premature infants is unknown. We measured RBC Fe incorporation and fractional Fe absorption in 8 premature infants (birth weight 1.1 ± 0.2 kg, gestational age 29± 1 wk, weight at start of study 1.6 ± 0.2 kg) using a novel triple isotope technique in which 57Fe was given mixed with 2 feedings of Enfamil Premature Formula (EPF) (Mead Johnson, Evansville, IN), 54Fe was given as a supplement between feeds with a multivitamin preparation, and 2 wk later 58Fe was given intravenously (IV). RBC incorporation was calculated from the enrichment of each isotope in a blood sample collected 14-15 days after isotope administration using a blood volume estimate of 80 ml/kg. Fractional absorption was calculated by dividing the RBC incorporation of 54Fe and 57Fe by the RBC incorporation of the 58Fe. All samples were analyzed for isotope ratios using magnetic sector thermal ionization mass spectrometry.Table
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