Abstract
The growing resistance of pathogens to conventional antibiotics has become a public health problem requiring novel effective solutions. In this context, metal‐organic frameworks (MOFs) are attracting attention because they can act as reservoirs releasing metal ions with antibacterial properties. This action is reminiscent of that proposed for metal‐ and metal oxide‐nanoparticles but different from the action of antibiotics. These features make MOFs promising candidates for pharmaceutical and biomedical applications. Here, IRMOF‐3 was modified with 2,5‐dimethoxytetrahydrofuran, N,N′‐disuccinimidyl carbonate, acryloyl chloride, and phthalaldehyde to produce, respectively, IRMOF‐3‐FU, IRMOF‐3‐SU, IRMOF‐3‐AC, IRMOF‐3‐DL in 38 to 90 % yields. Remarkably, the biological activity of these compounds evaluated against various bacterial and fungal strains is higher than the activity of commercial antibiotics.
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