Abstract
Functional imaging complements T2-weighted imaging in the evaluation of the prostate. The most frequently used techniques are diffusion-weighted imaging and perfusion imaging following the intravenous administration of contrast material. Perfusion imaging has high sensitivity and moderate specificity, even when using a quantitative technique, because contrast kinetics in some cases of peripheral zone prostatitis and benign transition zone hyperplasia may simulate cancer. Diffusion-weighted imaging is currently under evaluation but appears to be preferable to dynamic perfusion MR imaging because of its higher specificity and simpler acquisition. Functional imaging of the prostate is performed to detect cancers missed on biopsies or evaluate the volume of a newly diagnosed clinically localized cancer to assist in therapy selection. Future applications for image-guidance of targeted therapies to the tumor are currently investigational.
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