Irisin osteoporoz tedavisi takibinde kullanılabilir mi?

Abstract

Aim: This study aims to investigate the possible roles of irisin as a biomarker in the diagnosis and follow-up of osteoporosis.Methods: A total of 32 postmenopausal osteoporotic and 23 healthy postmenopausal women were received in this study. Bone mineral densitometry (BMD) measurements were done for all patients and control groups. Clinical follow-ups were performed every 3 months. To elicit post-treatment values, at the end of the 12-month follow-up period, all patients underwent BMD and biochemical parameters. Serum irisin concentrations were measured by competitive Enzyme-Linked Immunosorbent Assay (ELISA). The detection range of the used kit was 0.5-30 ng/ml.Results: T-scores were determined as -3.28±0.6 in the BT group (Before treatment) and -2.49±0.7 in the AT group (After-Treatment), and -0.7±0.4 in the control group (C). Significant differences were observed in T scores between BT and AT (p<0.001), BT and C (p<0.001), and AT and C (p<0.001) statistically. Significant differences were observed between BT and C (p<0.001) and AT and C (p=0.002) statistically. There was no significant difference between BT and AT values (p=0.327) statistically. At the correlation analysis, irisin was positively correlated with T score (p=0.01, r=0.25) and 25-OH-D (p=0.02, r=0.23), and negatively correlated with development of osteoporosis (p=0.02, r=-0.23). According to the ROC analysis, irisin levels of 4.1 ng/ml or less can predict pre-treatment osteoporosis with 65.6% specificity and 60% sensitivity (AUC: 65.8%, p=0.014).Conclusion: We concluded that irisin was a protective factor against osteoporosis. It may be used as a biomarker in the diagnosis of osteoporosis.