Iris Melanoma: Genetic Pathway, Staging, Histopathology, Clinical Features, Diagnostic Imaging, Treatment and Management

Abstract

Introduction- Iris melanomas mainly grow in the anterior chamber or along the iris surface, and by local extension; they commonly invade the anterior chamber angle and anterior ciliary body. Iris melanomas account for 2–3% of all uveal melanomas, with the diffuse variety accounting for about 10% of all iris melanomas. Methodology-A systematic review is a technical tool that basically describes a more or less systematic way of collecting and synthesizing past research by integrating findings and perspectives from a variety of empirical findings. In this study, authors conducted a systematic assessment of 51 research articles on the subject of "Iris Melanoma" in order to examine and compare the various approaches and outcomes. This comprehensive review summarizes all 51 research articles in the most accessible manner to discuss the Genetic pathway, Staging, Histopathology, Clinical features, Diagnostic Imaging, Treatment, and Management. Results-Iris melanomas are discovered early and treated fast because they are apparent when they are little. As a result, patients with this tumor had a better prognosis than those with posterior uvea tumors. Conclusion- Radiotherapy or surgical resection are usually used in this situation. A combination of radiotherapy and surgery may be employed in some circumstances. Conservative treatment is an excellent option for enucleation since it provides for effective tumor control locally. Keywords:melanoma, Diagnosis, Management, Stages, Eye-care.