Iridoid and Phenylethanoid Glycosides from Phlomis nissolii and P. capitata

Abstract

Abstract A new iridoid glucoside, lamiidic acid was isolated from Phlomis nissolii, along with one known iridoid glucoside, lamiide and 13 phenylethanoid glycosides, verbascoside, isoverbascoside, leucosceptosides A and B, martynoside, arenarioside, forsythoside B, alyssonoside, lamiophlomiside A, samioside, integrifoliosides A and B, and hattushoside. A new iridoid glucoside, ipolamiidic acid was isolated from Phlomis capitata together with two known iridoid glucosides, lamiide and ipolamiide. The known phenylethanoid glycosides, isoverbascoside, forsythoside B, alyssonoside and hattushoside, a known lignan glycoside, liriodendrin, three flavonoid glycosides, luteolin 7-O- (6”-O-α-L-rhamnopyranosyl)-β -D-glucopyranoside, luteolin 7-O-(6”-O-β -D-apiofuranosyl)-β -Dglucopyranoside and chrysoeriol 7-O-β -D-glucopyranoside, an acyclic monoterpene, betulalbuside A, and a quinic ester derivative, chlorogenic acid were also obtained and characterized. The structures of the isolated compounds were elucidated by means of spectroscopic (HRESI-MS, 1D and 2D NMR) evidence.