IRF5-TNOP3 polymorphisms are associated with elite control of HIV infection: A retrospective study.

Abstract

IRF5-TNPO3polymorphisms have previously been related to immune response, and TNPO3 plays a role inhuman immunodeficiency virus(HIV)-1infection after nuclear import. Therefore, we analyzed the genetic association between IRF5-TNPO3 polymorphisms and the HIV elite control in long-term nonprogressors (LTNPs). We performed a retrospective cohort study on 183 LTNPs, who were antiretroviral therapy-naïvewith CD4+ ≥ 500 cells/mm3 , viral load ≤10 000 copies/mL, and asymptomatic over 10 years after HIV seroconversion. The primary outcome variable was HIV elite control (undetectable viral load in at least 90% of the measurements for at least 1year). Seven IRF5-TNPO3polymorphisms were genotyped using Agena Bioscience's MassARRAY platform. We found a significant association between specific IRF5-TNPO3genotypes and HIV elite control: rs2004640 TT (aOR = 2.05;p = 0.041), rs10954213 AA (aOR = 1.95;p = 0.035), rs2280714 TT (aOR = 2.02;p = 0.031), and rs10279821 CC (aOR = 2.12;p = 0.017). We also found a significant association between IRF5-TNPO3haplotype TATC composed of the favorable significant polymorphisms (rs2004640, rs10954213, rs2280714, and rs10279821) and the HIV elite control (aOR = 1.59;p = 0.048).IRF5-TNPO3rs2004640, rs10954213, rs2280714, and rs10279821 polymorphisms were related to HIV elite control in LTNPs. Our data provide new knowledge about the impact of IRF5-TNPO3polymorphisms on HIV pathogenesis to understand the phenomenon of natural HIV control.