Abstract
Objectives: Adverse conditions in the ovarian cancer (OvCa) tumor microenvironment (TME) result in sustained activation of the inositol-requiring enzyme 1 alpha (IRE1α)-X-box binding protein 1 (XBP1) arm of the endoplasmic reticulum (ER) stress response. This evokes chronic changes in immunometabolic processes that subsequently inactivate the anti-tumor functions of dendritic cells and T cells, thereby creating an immunosuppressive TME capable of the limiting the effectiveness of immunotherapies in OvCa.
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