Abstract
With the IR-spectroscopy method and the quantum-chemical AM1 method, the Δ22 and Δ23 steroids containing a hydroxyl group at C20 or C22 have been studied in order to elucidate the mutual arrangement in space of the hydroxyl group and of the double bond in the side chain of the molecules. The conformational analysis of steroid alcohols has been performed and the population of their stable conformers has been calculated. The frequencies of the bands in the IR spectra of alcohols in the region of the stretching vibration of OH groups have been assigned to certain conformers and the possibility of formation of the intramolecular hydrogen bond of the OH groups with the π-electron cloud of C=C bonds has been analyzed.
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