Abstract
These results demonstrate that only splenic macrophages expressing both Ir products (function) and the antigen (GAT) were able to reconstitute the T cell response of cultures in which the splenic macrophage monolayer had been treated with appropriate anti I-A antibodies. This inhibition was not a result of induced suppression caused by anti-Ia treatment but rather a masking of Ia antigen which prevents the T cell receptor(s) from recognizing either the Ir gene product and specific antigen in complex or separately.
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