Abstract
Background. Uveitis is 20 times more frequent in multiple sclerosis (MS) patients than in the general population. Methods. A retrospective study of local multiple sclerosis (n = 700) and uveitis cohorts (n = 450) described the ophthalmological and neurological characteristics of patients with multiple sclerosis and uveitis. Results. Uveitis and multiple sclerosis were associated in seven patients. The time intervals between diagnoses of MS and uveitis ranged from 6 months to 15 years. Analysis of the patients' characteristics revealed that multiple sclerosis was associated with an older age of onset than usually expected, that is, 39 years. Uveitis was bilateral in three cases and mainly posterior (5/10). Five patients presented with acute optic neuritis (two in one eye and three in both eyes). All eyes presenting with acute optic neuritis were also affected by uveitis (P = 0.02), though not simultaneously. Conclusion. The ipsilateral association between optic neuritis and uveitis in this series of patients with multiple sclerosis may suggest a reciprocal potentiation between optic neuritis and uveitis in multiple sclerosis.
Highlights
Optic neuritis (ON) is the most frequent ophthalmic manifestation of multiple sclerosis (MS), occurring in ∼30% of cases
There were no simultaneous manifestations of MS and uveitis
The time intervals between diagnoses ranged from 6 months to 15 years (Table 1)
Summary
Optic neuritis (ON) is the most frequent ophthalmic manifestation of multiple sclerosis (MS), occurring in ∼30% of cases. Uveitis is 20 times more frequent in multiple sclerosis (MS) patients than in the general population. A retrospective study of local multiple sclerosis (n = 700) and uveitis cohorts (n = 450) described the ophthalmological and neurological characteristics of patients with multiple sclerosis and uveitis. Uveitis and multiple sclerosis were associated in seven patients. Analysis of the patients’ characteristics revealed that multiple sclerosis was associated with an older age of onset than usually expected, that is, 39 years. Five patients presented with acute optic neuritis (two in one eye and three in both eyes). The ipsilateral association between optic neuritis and uveitis in this series of patients with multiple sclerosis may suggest a reciprocal potentiation between optic neuritis and uveitis in multiple sclerosis
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