Abstract
IP3 3-kinase B prevents bone marrow failure
Highlights
The Greek philosopher Plato emphasized the importance of moderating personal desires for the functioning of society
Activated by cytokines and other signals, phosphoinositide 3-kinases (PI3K) and its effectors Akt and mTORC1 are required for hematopoietic stem cells (HSC) self-renewal and function
To determine if IP4/PIP3-antagonism moderates PI3K-signaling in HSC, we studied Itpkb-/- mice
Summary
The Greek philosopher Plato emphasized the importance of moderating personal desires for the functioning of society. This is critical, because continuous HSC-activation reduces self-renewal and depletes HSC, causing BM failure and immunodeficiencies, and promoting certain blood cancers [1, 2, 4]. Increasing evidence suggests that signaling from cytokines like SCF in dormant HSC must be tuned into an intensity-range that ensures self-renewal, but avoids activation. Activated by cytokines and other signals, PI3K and its effectors Akt and mTORC1 are required for HSC self-renewal and function.
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