Abstract
Interaction of σ receptors with intracellular Ca 2+ channel blocker and modulators was examined. Ryanodine and inositol 1,4,5-trisphosphate (IP 3) did not inhibit [ 3H](+)- N-allylnormetazocine ([ 3H](+)-SKF-10047) binding to σ receptors from either brain microsomal fractions or liver membrane extracts of the rat. However, the IP 3 receptor antagonist heparin inhibited [ 3H](+)-SKF-10047 to σ receptors in an uncompetitive manner with a K i of 93 μM. These results suggest that σ receptors may bear some relationship with IP 3 receptor associated proteins or channels.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.