IOP measurement from corneal vibration parameters analysis: first clinical trial partial results

Abstract

AbstractPurpose A novel non‐contact, non‐invasive Vibration Tonometry technology with excitation of corneal vibration and their correlation to GAT IOP was tested in a large clinical trial reportedMethods 413 eyes from 207 volunteers from various origins at a suburban Paris hospital eye clinic were enrolled. History, vibration tonometry measurements in triplicate GAT, NIDEK air puff IOP, refractometry, keratometry and Tomey pachymetry. Algorithm discovery was performed by random draw splitting runs into a discovery sample and a separate validation sample performed 10 times separately on males and females.Results 40/207 19.3% patients had glaucoma,50% were females.993 measurement runs were performed of which 83.5% were in correct position. Population aged 23‐92 yo with 42% females with mean 59.7(+/‐15.7) in females and 60.4 (+/‐13.8)in males. GAT IOP mean was 16.0 mm Hg (+/‐3.46) in females and 15.8 (+/‐3.95) in males. CCT mean was 530.2µ (+/‐35.1) in females and 526.3µ (+/‐42.4) in males, AL mean was 23.29 mm (+/‐1.68) in females and 23.73 mm (+/‐1.68) in males. None of these differences were significant. 46 eyes had GAT IOP greater >/= 20 mm Hg. No adverse events were reported during or post trial. Algorithm for women yielded 95,4% of IOP mean within 5 mm Hg of mean GAT IOP. For men 91% of IOP mean was within 5 mm Hg of mean GAT IOPConclusion Current algorithm seems to show no evidence of effect of CCT on measurement precision. Vibration tonometry is a valuable method for non‐invasive measurement of IOP without contact with reasonable precision and good reproducibility and independently of CCT. It may thus prove to be a valuable tool for IOP measurement in thin and surgical corneas Commercial interest