Abstract
The effects of 2-phenylethylamine (PEA) and of its metabolite 2-hydroxy-2-phenylethylamine (OHPEA) were compared with those of norepinephrine (NE) on spontaneously active single optic cortex neurons of rabbit. A multiple barrel microelectrode array was used for the microiontophoretic drug administration and simultaneous extracellular unit recordings. PEA and OHPEA exerted effects opposite to those of NE on several of the cortical units tested suggesting that the effects of PEA and OHPEA were not mediated through NE release or activation of NE receptors.
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