Abstract
Calcitonin gene-related peptide (CGRP) was applied by iontophoresis onto physiologically characterized neurons. CGRP (20–100 Na) activated both wide-dynamic-range ( 5 8 ) and low-threshold mechanoreceptive units ( 3 12 ), but had no effect on nociceptive-specific neurons ( 0 4 ). The excitation was of slow onset (30 s to 3 min) and prolonged duration (up to 10 min). In none of the tested units did CGRP cause inhibition. The slow and prolonged action suggests a neuromodulatory role for CGRP in spinal cord sensory processes.
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