Ionic Polymer Supported Copper(I): A Reusable Catalyst for Huisgen’s 1,3-Dipolar Cycloaddition

Abstract

A series of CuI-immobilized polymeric supports having quaternary ammonium salts were prepared as recyclable heterogeneous catalysts with evaluation of their ability in Cu(I)-catalyzed Huisgen’s 1,3-dipolar cycloaddition of azides and terminal alkynes, a ‘click reaction’. An ionic polymer possessing an acetate anion was suitable as the solid support for immobilization of CuI and CuI-immobilized compound showed negligible leaching levels of CuI, providing 1,4-disubstituted 1,2,3-triazoles in good yields, regio-selectively. The CuI-immobilized compound was also reused not only up to ten times without any loss of yield or catalytic activity, but also for twelve different click reactions.