Abstract
Ionic mechanisms of action potential propagation velocity changes in peripheral C-fibers. Implications for pain
Highlights
C-fibers, nonmyelinated afferent axons, convey information from the periphery of the nervous system to the spinal cord
We use ion channel models based on Hodgkin Huxley formalism
We find that TTX- sensitive Na and Nav1.8 have the strongest influence on conduction velocity (CV) as is expected since these are the major components of the rising phase of the action potential
Summary
C-fibers, nonmyelinated afferent axons, convey information from the periphery of the nervous system to the spinal cord. They transmit signals originating from stimulus of temperature, pressure and tissue damage producing sensations of itch and pain. It is generally believed that underlying mechanisms include changes in ion channel conductances. These changes should be reflected in changes in the membrane potential. ADS is known to be dependent on CV [4] which in turn has been suggested to be dependent on the conductances of the voltage gated sodium channels[1] [2][3].
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