Abstract
In order to meet the increasing demand for environmentally benign chemical processes, we developed a Suzuki–Miyaura reaction protocol based on the combination of ohmic heating (ΩH) and supported ionic liquid phase catalysis (SILPC) in aqueous media. This methodology was applied to the synthesis of a series of flavonoid derivatives, including isoflavones, styrylisoflavones, and diarylalkenylisoflavones.
Highlights
Pd-catalyzed cross-coupling reactions exemplify one of the most powerful and popular methods for the formation of carbon–carbon bonds [1]
A further advantage of basing Pd-catalyzed cross-coupling reactions in supported ionic liquid phase catalysis (SILPC) is that such reactions are usually performed in water and are significantly enhanced by microwave (MW) heating
Suzuki–Miyaura reactions, have proven for the synthesis of pharmacoHerein we describe the combination of ΩH
Summary
Pd-catalyzed cross-coupling reactions exemplify one of the most powerful and popular methods for the formation of carbon–carbon bonds [1]. A further advantage of basing Pd-catalyzed cross-coupling reactions in SILPC is that such reactions are usually performed in water and are significantly enhanced by microwave (MW) heating. Palladium-catalyzed cross-coupling reactions are gaining much recent interest [21,22,23,24,25,26,27], being the Suzuki–Miyaura coupling reaction the reported for the synthesis of flavonoid derivatives. Suzuki–Miyaura reactions, have proven useful for the synthesis of pharmacologically most frequently used methodology [28] In this regard, ΩH-enhanced cross-coupling reactions, and relevant scaffolds [29,30]. Describe the combination of ΩH and SILPC for the Suzuki cross-coupling reaction and its application to the synthesis and functionalization of flavonoids
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