Abstract

The ionic liquid, 1-butyl-3-methylimidazolium chloroaluminate, [bmim]Cl·AlCl 3, N=0.67 mediated syntheses of aromatic sulfonamides via electrophilic substitution of arenes is reported. The protocol serves as a distinctly expeditious and ambient route towards the syntheses of these pharmaceutically useful compounds, yielding quantitative conversions at room temperature within 5–30 min in most of the cases. The Lewis acidity and molar stoichiometry of the ionic liquid influences the extent of conversion. The method has been used for the syntheses of a diverse range of sulfonamides by variation of arenes and sulfamoyl chlorides. With monosubstituted benzenes, the protocol offers an added advantage of exclusive selectivity towards the formation of para substituted sulfonamides over the ortho products.

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.