Ionic Liquid-Assisted Hydrothermal Synthesis of a Biocompatible Filler for Photo-Curable Dental Composite: From Theory to Experiment.

Kh Moradi,A.A Sabbagh Alvani,D Poelman

doi:10.3390/ma12142339

Kh Moradi, A.A Sabbagh Alvani + Show 1 more

Open Access

https://doi.org/10.3390/ma12142339

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Journal: Materials	Publication Date: Jul 23, 2019
Citations: 2	License type: CC BY 4.0

Affiliation: Amirkabir University of Technology, Ghent University

Abstract

Nanostructured hydroxyapatite (HA) is a new class of biocompatible fillers which has been recently utilized in bio hybrid materials by virtue of its excellent tissue bioactivity and biocompatibility. However, the need for higher thermal stability, solubility, surface bioactivity, radiopacity, and remineralization ability suggests a divalent cation substitution of HA for use in light curable dental restorative composites. In this work, structural and optical properties of Sr-doped hydroxyapatite were studied using first-principle calculations based on density functional theory (DFT). Next, Sr-doped hydroxyapatite (HA) was prepared via a new ionic liquid-assisted hydrothermal (ILH) route. Samples were characterized using X-ray diffraction (XRD), scanning electron microscopy (SEM)/energy dispersive spectroscopy (EDS), Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), dynamic light scattering (DLS), Brunauer–Emmett–Teller (BET) surface area analysis, and cell viability. The obtained experimental data showed that the nucleation and crystal growth process controlled by [BMIM]Br molecules results in uniform products with small and regular particles and high specific surface areas. Finally, cytotoxicity tests showed that the as-prepared Sr-doped HA nanoparticles have good biocompatibility (≥91%), confirming their potential for use in photo-curable dental restorative composites.

Highlights

Hydroxyapatite (HA, Ca10 (PO4 )6 (OH)2 ) is one of the most promising bioactive materials for the production of artificial bone grafts and teeth joints with good osteoconductive and biocompatible properties for biomedical applications [1,2,3]
Sr-doped HA nanoparticles was synthesized via a modified hydrothermal route with
Sr-doped HA nanoparticles was synthesized via a modified hydrothermal route the assistance of [BMIM]Br ionic liquid and the resultant products were comprehensively characterized

Summary

Introduction

Hydroxyapatite (HA, Ca10 (PO4 ) (OH)2 ) is one of the most promising bioactive materials for the production of artificial bone grafts and teeth joints with good osteoconductive and biocompatible properties for biomedical applications [1,2,3]. The substitution of divalent cations, such as Sr for Ca, in the lattice structure of HA modifies its thermal stability, solubility, and textural properties, as well as its surface reactivity. These substitutions can significantly promote the biological response, radiopacity, and remineralization ability of pure HA for dental restorative composite applications [8,9,10,11,12]. Several in vitro studies demonstrated that collagen type I production and remineralization of caries lesions can be facilitated by the release of strontium from dental composites [13,14].

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