Abstract
It has been assumed that skin wound currents are produced by passive ion leakage from wounded skin. However, what ions contribute to the skin wound current? Thirty male C57BL/6 mice were used in this study. A lancet wound (about 5mm in length) was made by cutting into the full thickness skin. We measured the dynamic time courses of individual ion flux with ion-selective probes at skin wound. The probe is aligned perpendicular to the surface of skin wound. All ions (Na+, Cl-, K+, Ca2+ and H+) showed a small steady efflux at unwounded mouse skin. However, there were large efflux of Na+, Cl-, K+, Ca2+ and H+ 15 minutes after wounding. These values maintained for 534 seconds, which were significantly higher than the ions flux of intact skin (P< 0.05). Our results suggest that Na+, Cl-, K+, Ca2+ and H+ contribute to the wound currents at skin wounds. A most significant observation is that the skin wound currents are carried mainly by the largest sodium and chloride efflux, then potassium, while the calcium and hydrogen are the least.
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