Abstract
The electrical activity of vertebrate hair cells, including mechanoelectrical transduction, resonant frequency tuning, and synaptic transmission, results from the action of an ensemble of ionic channels. In an effort to understand how hair cells function as the sensory receptors of the internal ear, our research group is conducting in vitro investigations of the ionic channels of saccular hair cells from the bullfrog, Rana catesbeiana.Mechanoelectrical transduction commences when stimuli, derived from sounds or accelerations, deflect the hair bundle, a cluster of enlarged microvilli termed stereocilia.
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