Abstract
AbstractPotential acylating agents containing pendant ionic groups have been screened for the enzymatic kinetic resolution of rac‐secondary alcohols in ionic liquids with CAL‐B as biocatalyst. This study has allowed the identification of the 1‐methyl‐3‐alkylimidazolium cation attached to a carboxylate group through a C10‐alkyl chain as an efficient acylating agent for this transformation. This strategy was applied to the resolution of 2‐hydroxycyclohexanecarbonitrile in which the 1R,2S enantiomer was isolated in 35 % ee (73 % yield) and the 1S,2R enantiomer in 97 % ee (23 % yield).
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