Abstract
AbstractA dynamic combinatorial library (DCL) consisting of dialdehydes and diamines has been used to facilitate the transport of calcium ions across a supported liquid membrane (SLM). In a dual selection process, the calcium ions first select matching macrocycles 3 or 5 from the DCL. Then only one of the macrocycle–calcium complexes (5·Ca2+) efficiently transports the calcium ions due to its better balance between lipo‐ and hydrophilicity. The special setup of a DCL combined with an SLM directly finds suitable carriers for ion transport starting from diamine and dialdehyde building blocks 1, 2 and 4. The synthesis of the new, more lipophilic 4‐pentoxypyridine‐2,6‐dicarbaldehyde (4) is also described, and the first transport experiments with liposomes are discussed.
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