Abstract
Most ion-selective electrodes (ISEs) developed so far for determination of drugs are based on the use of ion-exchange systems. If the drug involves compounds containing organic anions, then most often quaternary ammonium salts are used for their conversion to an electrode-active substance [1 – 7]. In particular, for determination of anions of the sulfanilamide drugs norsulfazole, sulfadoxin, and sulfamethoxazole, the membranes include their cetyltriphenylphosphonium [8] and cetyltrioctylammonium [9] associates. But the electrodes described have a narrow range of linearity for the electrode function and rather considerable potential drift. Comprehensive studies are lacking on the potentiometric properties of ion-selective electrodes reversible to sulfanilamide drugs. Accordingly, design of new ion-selective electrodes for determination of sulfanilamide drugs is a promising approach.
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