Abstract
Stimuli-responsive contrast agents (CAs) show great promise for the early detection and understanding of cancer. In particular, CAs that respond to ion content may allow monitoring of both the development of cancer and the efficacy of novel therapies. Understanding the responsive behavior of stimuli-responsive CAs in different ionic environments requires development of more advanced characterization methods. Here we report a high-resolution NMR and molecular dynamics (MD) study of conformational changes of ion-responsive 19F copolymers of oligo(ethylene glycol) methyl ether methacrylate (OEGMA) and 2,2,2-trifluoroethyl acrylate (TFEA) (poly(OEGMA-co-TFEA)) in the presence of salt. 1H 2D NOESY spectra were collected with and without the presence of NaCl and demonstrated that further separation of OEGMA and TFEA segments and closer association of OEGMA side chain were observed with the addition of NaCl. MD simulations provided additional information on the changes in conformation and were consistent with th...
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