Abstract
Studies of ion pair formation and permeation in non-aqueous media through model synthetic membranes were performed with the aim of lipophilization of ionic drugs for transport across hydrophobic barriers. Ion pair formation was characterized utilizing conductivity, NMR and electromotive force. The permeation experiments were performed using 3 model hydrophobic membranes, dense hydrophobic, porous hydrophobic and hydrophobic-hydrophilic balanced membranes. It was found that the ion-paired drugs attained electrical neutrality and lipophilic characteristics and consequently, had enhanced permeation through hydrophobic membranes. Both partition and pore mechanisms contributed to ion pair diffusion.
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